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For your convenience, here are some frequently asked questions and answers about NORTHERA® (droxidopa) and symptomatic neurogenic orthostatic hypotension (nOH). Select each question to reveal the answer:

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Orthostatic hypotension (OH) is a condition in which there is a sustained drop in blood pressure after a person stands or sits up. Neurogenic orthostatic hypotension (nOH) is a type of OH that is associated with a nervous system disorder, such as Parkinson’s disease (PD), multiple system atrophy (MSA), or pure autonomic failure (PAF). People living with nOH can experience symptoms such as lightheadedness, and others can be asymptomatic, meaning they may not experience symptoms.

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Supine hypertension is high blood pressure when lying down. You may have high blood pressure when lying down for many of the same reasons you have low blood pressure when standing up. The damage caused by your nervous system disorder may also affect your body’s ability to control blood pressure when lying down.

Work with your healthcare provider as NORTHERA may cause or worsen supine hypertension (high blood pressure while lying down) in patients with nOH. If supine hypertension is not well-managed, NORTHERA may increase the risk of cardiovascular events, particularly stroke. You can reduce the risk of supine hypertension by keeping your upper body raised when lying down. You can do this by raising the head of your bed.

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NORTHERA (droxidopa) is a prescription medication used to reduce dizziness, lightheadedness, or the “feeling that you are about to black out” in adults who experience a significant drop in blood pressure when changing positions or standing (called symptomatic neurogenic orthostatic hypotension (nOH)) and who have one of the following:

  • Parkinson’s disease (PD), a neurodegenerative disease that causes slowness in muscle movement as well as shaking in the hands
  • Multiple System Atrophy (MSA), a Parkinson’s-like disorder with more widespread effects on the brain and body
  • Pure Autonomic Failure (PAF), a neurodegenerative disease that results in frequent drops in blood pressure upon standing
  • Dopamine Beta-Hydroxylase Deficiency, a condition where the body cannot make enough hormones that help regulate blood pressure
  • Non-Diabetic Autonomic Neuropathy, an inability to maintain blood pressure upon standing that can be caused by a number of rare diseases

Effectiveness beyond 2 weeks of treatment has not been established, and your doctor will decide if you should continue taking   NORTHERA.

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The exact way NORTHERA works in treating symptomatic neurogenic orthostatic hypotension (nOH) is not known. However, NORTHERA is converted to norepinephrine inside the body. One of the effects is a small and temporary increase in norepinephrine, a chemical that, among other functions, helps to regulate blood pressureLearn more.

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You should always follow the dose recommended by your healthcare provider. If you feel the dose isn’t right for you, then talk with your healthcare provider about making changes to your dose. There are some general dosing guidelines you can follow.

NORTHERA may cause allergic reactions. Stop taking NORTHERA and contact your doctor right away, or go to the nearest emergency room if you experience any signs or symptoms of an allergic reaction such as: fast heartbeat, nausea, vomiting, swelling, trouble breathing, hives, or rash. NORTHERA contains tartrazine (FD&C Yellow No. 5), which may also cause an allergic reaction, especially if you have had a reaction to aspirin.

Do not take NORTHERA if you have a known allergy to NORTHERA or its ingredients.

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Yes, NORTHERA can be taken with or without food. However, it should be taken the same way every time. Therefore, if it is taken with food, then it should always be taken with food.

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You should take NORTHERA as prescribed by your healthcare provider. Effectiveness beyond 2 weeks of treatment has not been demonstrated.

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The NORTHERA Support Center will contact your insurance company to determine your coverage for NORTHERA once it receives a completed NORTHERA Treatment Form from your healthcare provider. Questions regarding insurance coverage should be directed to your insurance company and/or healthcare provider.

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As with any prescription medication, there are potential side effects and safety considerations you should be aware of before starting NORTHERA. The most common side effects with NORTHERA are headache, dizziness, nausea, and high blood pressure. WARNING: SUPINE HYPERTENSION (this is high blood pressure while lying down). When lying down, elevating the head and upper body lowers the risk of high blood pressure. Check your blood pressure in this position prior to starting and during NORTHERA treatment. If you experience high blood pressure, talk to your doctor about your NORTHERA treatment. Learn more.

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You can call the NORTHERA Support Center toll-free at Monday through Friday, 8 AM to 8 PM, EST.

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Titration is the process of slowly increasing the dose of your medication to find the dose that works for your symptoms. The titration and dosing schedule may vary by individual.

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Yes, there are organizations and online communities that offer support to people living with symptomatic nOH and nervous system disorders. Learn more.

IMPORTANT SAFETY INFORMATION

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WARNING: SUPINE HYPERTENSION (this is high blood pressure while lying down)

When lying down, elevating the head and upper body lowers the risk of high blood pressure. Check your blood pressure in this position prior to starting and during NORTHERA treatment. If you experience high blood pressure, talk to your doctor about your NORTHERA treatment.

IMPORTANT SAFETY INFORMATION

EXPAND

WARNING: SUPINE HYPERTENSION (this is high blood pressure while lying down)

When lying down, elevating the head and upper body lowers the risk of high blood pressure. Check your blood pressure in this position prior to starting and during NORTHERA treatment. If you experience high blood pressure, talk to your doctor about your NORTHERA treatment.

For more information, please see the full Prescribing Information, including Boxed Warning for supine hypertension.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.