What is Symptomatic nOH?
Static on screen throughout entire video: “Please listen to the Important Safety Information in this video.” On bottom of screen throughout entire video.
Gail: Hi, I am Gail and I have Parkinson’s disease with symptomatic nOH.
Gail looks at her sheet music.
Gail: Symptomatic nOH is a condition in which when you stand your blood pressure drops.
Gail lies on the couch removing glasses and rubbing eyes.
Gail: When I would have an episode of symptomatic nOH, I would feel very lightheaded, I would feel very dizzy, I really felt like I was going to faint.
Gail: I didn’t tell the doctor for a while because I just thought that’s what having Parkinson’s disease was. I didn’t understand the relationship between falling blood pressure and the symptoms I had and the fact that I had Parkinson’s.
Gail sits in a chair while playing the Recorder (musical instrument)
Gail: Getting the diagnosis of symptomatic nOH was such a relief.
Gail sits at a desk reading off of a laptop
Gail: I was able to let my family know that what I was experiencing was something that was not necessarily because I had Parkinson’s, it was something I had along with my Parkinson’s.
Indication and Important Safety Information scrolling and read by narrator.
Gail: These symptoms may be treatable. Please talk to your doctor.
Use
NORTHERA (droxidopa) is a prescription medication used to reduce dizziness, lightheadedness, or the “feeling that you are about to black out” in adults who experience a significant drop in blood pressure when changing positions or standing (called symptomatic neurogenic orthostatic hypotension (nOH)) and who have one of the following:
Effectiveness beyond 2 weeks of treatment has not been established, and your doctor will decide if you should continue taking NORTHERA.
IMPORTANT SAFETY INFORMATION
WARNING: SUPINE HYPERTENSION (this is high blood pressure while lying down)
When lying down, elevating the head and upper body lowers the risk of high blood pressure. Check your blood pressure in this position prior to starting and during NORTHERA treatment. If you experience high blood pressure, talk to your doctor about your NORTHERA treatment.
For more information, please see the full Prescribing Information, including Boxed Warning for supine hypertension.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-10881-800-FDA-1088.
Symptomatic nOH can occur in people who have Parkinson’s disease (PD), multiple system atrophy (MSA), or pure autonomic failure (PAF). People with symptomatic nOH may experience a sustained drop in blood pressure when standing up, changing positions, or standing for a long period of time. This may cause symptoms such as dizziness, lightheadedness, and the feeling that they are about to black out. There is no cure for symptomatic nOH, but NORTHERA® (droxidopa) may help reduce these symptoms.
After a person stands up, gravity pulls the blood to the lower part of the body, lowering the blood pressure. When this happens, the nervous system typically releases a chemical called norepinephrine, which signals the blood vessels to tighten, or constrict. This raises the blood pressure and makes it easier for the body to pump blood back up to the heart and brain.
In a person with symptomatic nOH, the body may not release enough norepinephrine when standing. As a result, the blood vessels are unable to tighten as they should. Blood pressure may remain low after standing, which prevents blood from moving back up to the heart and brain. This reduced blood supply to the brain is what can cause symptoms like dizziness, lightheadedness, and the feeling that one is about to black out.
People living with nOH may experience the following symptoms when standing up or changing positions, or after standing for a long period of time:
Use
NORTHERA (droxidopa) is a prescription medication used to reduce dizziness, lightheadedness, or the “feeling that you are about to black out” in adults who experience a significant drop in blood pressure when changing positions or standing (called symptomatic neurogenic orthostatic hypotension (nOH)) and who have one of the following:
Effectiveness beyond 2 weeks of treatment has not been established, and your doctor will decide if you should continue taking NORTHERA.
IMPORTANT SAFETY INFORMATION
WARNING: SUPINE HYPERTENSION (this is high blood pressure while lying down)
When lying down, elevating the head and upper body lowers the risk of high blood pressure. Check your blood pressure in this position prior to starting and during NORTHERA treatment. If you experience high blood pressure, talk to your doctor about your NORTHERA treatment.
For more information, please see the full Prescribing Information, including Boxed Warning for supine hypertension.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-10881-800-FDA-1088.
Please see Important Safety Information, including Boxed Warning for supine hypertension.
For more information, see the full Prescribing Information.
Use
NORTHERA (droxidopa) is a prescription medication used to reduce dizziness, lightheadedness, or the “feeling that you are about to black out” in adults who experience a significant drop in blood pressure when changing positions or standing (called symptomatic neurogenic orthostatic hypotension (nOH)) and who have one of the following:
Effectiveness beyond 2 weeks of treatment has not been established, and your doctor will decide if you should continue taking NORTHERA.
IMPORTANT SAFETY INFORMATION
WARNING: SUPINE HYPERTENSION (this is high blood pressure while lying down)
When lying down, elevating the head and upper body lowers the risk of high blood pressure. Check your blood pressure in this position prior to starting and during NORTHERA treatment. If you experience high blood pressure, talk to your doctor about your NORTHERA treatment.
For more information, please see the full Prescribing Information, including Boxed Warning for supine hypertension.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-10881-800-FDA-1088.